House

When the team takes on the case of Emily, a six-year-old girl with multiple health issues, they must collaborate with her mother, Elizabeth, who is also a doctor specializing in Emily's condition. Meanwhile, House and Wilson take a little vacation to treat Wilson's cancer in House's apartment.

Over his years performing autopsies at Princeton-Plainsboro Teaching Hospital, Dr. Peter Treiber often identifies mistakes made by physicians that caused the patient's death. These observations make him question the skills of nearly all the doctors on staff, all that is, except House. When he falls ill, he demands that only House make medical decisions concerning his care. Unfortunately, House and Wilson have taken off on an impromptu road trip without telling anyone, leaving the team to figure out how to treat Treiber while making him believe that House is calling all the shots. Lastly, Chase decides to step out of House's shadow and leave the hospital.

The team takes on the case of Derrick, a 19-year-old college student who had a mysterious nosebleed during cheerleading practice, and discovers that his health issues are likely both physiological and psychological. Possibly suffering from schizophrenia, Derrick claims to hear his deceased brother's voice in his head. Meanwhile, Foreman tries a different approach with House. Wilson and House continue to come to terms with Wilson's cancer.

Facing a 6-month jail term and realizing that he won't be there for Wilson at the end, House finds himself examining his entire life while contemplating a dismal future without his best friend. Trapped in a burning building, House must come to terms with his life, choices, personal demons, and future.