Spider-Man (2003)

Taking place after the 2002 "Spider-Man" theatrical blockbuster, "Spider-Man (2003)" was a new kind of Spider-Man cartoon featuring new graphics from Mainframe, the company behind "Reboot." The show follows young Peter Parker as he makes his way through college life, with his best friends Mary Jane Watson and Harry Osborn at his side. Spidey battles old and new faces (from Kraven the Hunter to a newbie known as the Talon). "Doogie Howser, M.D." alumnus Neil Patrick Harris lends his amazing vocal talent as the webslinger.
Did You Know?:

That the original concept for this series was going to be based off the Ultimate Spider-man comics? However, the idea was scrapped due to the idea to make an animated series based off the continuity set in the live-action Spider-man world.